Organized April 22, 1837, the nineteen original members of Antioch Baptist Church worshiped in a small log building until the stone church was erected in 1842. Baptisms were held in the creek behind the church. In 1901, the congregation tore down the stone church because of structural damage and erected the present building. The Women's Missionary Society acquired the adjacent log house in 1926 and deeded it to the church in 1957. In 1962, the church was closed due to dwindling congregation, but was re-opened in 1996.