For my Fiance and I, most of our wedding party are our siblings and their spouses. Both of us chose responsible, close friends as our maid of honor and best friend over our siblings, who are both introverts and too busy to deal with the demands of being in the top spot. But other than our maid of honor and best man, our wedding party is our siblings and their spouses.
Traditionally, it would make sense for us to have our blood relatives lined up closest to us and then the sibling-in-laws towards the outskirts of the wedding party. But with most of the wedding party having spouses, it would also make sense for husbands and wives to be paired together for pictures and to walk down the aisle together. I would lean towards everyone being paired with their spouse, but that could make for a weird line up where my sister-in-law is closer to me than my own sister just so she could be paired with her husband who's the brother of the groom (or opposite, my groom's future brother-in-law would be closer to him than his own brother if my sister was closer inside the line up).
Thoughts about what to do? We're already kicking tradition a bit by selecting friends over relatives for our best man and maid of honor, but I don't want our relatives to feel slighted by moving them futher down the line. Maybe it doesn't matter that husband and wives don't enter and exit the wedding ceremony together, but that could also look weird as to why they aren't with their spouse, and it's a lost photo opportunity for the couple if they aren't with their spouse.